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Sibutramine was originally developed in 1988 by Boots in Nottingham, U.K., and marketed by Knoll Pharmaceuticals after BASF/Knoll AG purchased the Boots Research Division in 1995, and was most recently manufactured and marketed by Abbott Laboratories before its withdrawal from most markets.
This medication has been sold under a variety of brand names including Reductil, Meridia, Siredia, and Sibutrex.
It is classified as a Schedule IV controlled substance in the United States.
It assists with weight-loss by altering neurotransmitters within the brain. Neurotransmitters are chemicals that are produced and released by nerves in order to communicate with other nerves.
Released neurotransmitters may attach to other nerves or they may be taken up again by the nerves that release them, a process termed reuptake.
This medication blocks the reuptake of the neurotransmitters dopamine, norepinephrine, and serotonin.
Blocking the reuptake of neurotransmitters alters the balance of neurotransmitters within the nerve cells and affect nerve function and interaction.
It has a number of clinically significant interactions. The concomitant use of this drug and monoamine oxidase inhibitors (MAOIs, such as selegiline) is not indicated, as it may increase the risk of serotonin syndrome, a somewhat rare but serious adverse drug reaction.
it should not be taken within two weeks of stopping or starting an MAOI.
Taking both and certain medications used in the treatment of migraines—such as ergolines and triptans—as well as opioids.
May also increase the risk for serotonin syndrome, using than one serotonin reuptake inhibitor at the same time.